Minimal Residual Disease Assessment in the Context of Multiple Myeloma Treatment
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چکیده
منابع مشابه
Minimal Residual Disease Assessment in the Context of Multiple Myeloma Treatment
With contemporary therapeutic strategies in multiple myeloma, heretofore unseen depth and rate of responses are being achieved. These strategies have paralleled improvements in outcome of multiple myeloma patients. The integration of the next generation of proteasome inhibitors and antibody therapeutics promise continued improvements in therapy with the expectation of consistent depth of respon...
متن کاملMinimal residual disease in multiple myeloma.
Multiple myeloma (MM) is a B-cell malignancy in which abnormal, clonal plasma cells proliferate and accumulate in the bone marrow. These abnormal cells, referred to as myeloma cells, disrupt normal bone marrow function and invade bone. Myeloma cells produce and secrete significant quantities of monoclonal protein (M-protein) into the blood and/or urine.1 The clinical features of MM include hype...
متن کاملThe prognostic value of multiparameter flow cytometry minimal residual disease assessment in relapse multiple myeloma
and San Miguel JF. The prognostic value of multiparameter flow cytometry minimal residual disease assessment in relapse multiple myeloma. Publisher's Disclaimer.0 E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts that have completed a regular peer review and have be...
متن کاملThe prognostic value of multiparameter flow cytometry minimal residual disease assessment in relapsed multiple myeloma.
Achieving deep levels of remission is one of the prerequisites to reach long-term survival in solid tumors and hematologic malignancies, and this has also been proved in newly diagnosed multiple myeloma (MM) patients, particularly in the era of novel agents. Accordingly, both the Spanish and UK groups have shown the prognostic value and clinical relevance of minimal residual disease (MRD) monit...
متن کاملNew criteria for response assessment: role of minimal residual disease in multiple myeloma.
Assessment of minimal residual disease (MRD) is becoming standard diagnostic care for potentially curable neoplasms such as acute lymphoblastic leukemia. In multiple myeloma (MM), the majority of patients will inevitably relapse despite achievement of progressively higher complete remission (CR) rates. Novel treatment protocols with inclusion of antibodies and small molecules might well be able...
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ژورنال
عنوان ژورنال: Current Hematologic Malignancy Reports
سال: 2016
ISSN: 1558-8211,1558-822X
DOI: 10.1007/s11899-016-0308-3